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English to Korean - Standard rate: 0.10 USD per word / 35 USD per hour / 12.00 USD per audio/video minute Korean to English - Standard rate: 0.12 USD per character / 40 USD per hour / 14.00 USD per audio/video minute Japanese to Korean - Standard rate: 0.10 USD per character / 35 USD per hour
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Sample translations submitted: 1
English to Korean: enzyme inhibition General field: Medical Detailed field: Biology (-tech,-chem,micro-)
Source text - English The activity of enzymes can be inhibited. Molecules that reduce an enzyme’s activity, called inhibitors, include many drugs, antibiotics, food preservatives, poisons, and metabolites of normal biochemical processes. The investigations of enzyme inhibition and inhibitors carried out by biochemists are important for several reasons. First, in living systems enzyme inhibition is an important means by which metabolic pathways are regulated. Numerous small biomolecules are used routinely to modulate the rates of specific enzymatic reactions so that the needs of the organism are consistently met. Second, numerous clinical therapies are based on enzyme inhibition. For example, many antibiotics and other drugs reduce or eliminate the activity of specific enzymes. The most effective AIDS treatment is a multidrug therapy that includes protease inhibitors, molecules that disable a viral enzyme required to make new virus. Finally, investigations of enzyme inhibition have enabled biochemists to develop techniques for probing the physical and chemical architecture, as well as the functional properties, of enzymes.
Enzyme inhibition can be reversible or irreversible. Reversible inhibition occurs when the inhibitory effect of a compound can be counteracted by increasing substrate levels or removing the inhibitor compound while the enzyme remains intact. Reversible inhibition will be competitive if the inhibitor and the substrate bind to the same site, noncompetitive if the inhibitor binds to a site other than the active site, and uncompetitive if the inhibitor binding site is created after the substate is bound to the enzyme. Irreversible inhibition occurs when inhibitor binding permanently impairs the enzyme, usually through a covalent reaction that chemically modifies the enzyme.
Translation - Korean 효소활성은 억제될 수 있다. 효소의 촉매 활성을 감소시키는 억제제라고 불려지는 물질에는 많은 약물, 항생제, 식품 보존제와 독극물 및 정상적인 생화학과정의 대사산물이 포함된다. 생화학자에 의해 수행되는 효소 억제와 억제제에 관한 연구는 여러 가지 이유에서 중요하다. 첫째, 생체에서 효소 억제는 대사경로가 조절되는 중요한 수단이다. 수많은 작은 생체분자는 생물이 필요로 하는 것을 지속적으로 충족되도록 특정 효소 반응의 속도를 조절하는데 일상적으로 사용된다. 둘째, 수많은 임상 치료는 효소 억제에 기반을 두고 있다. 예를 들어, 많은 항생제와 기타 약물들은 특정 효소의 활성을 감소하거나 또는 제거한다. 가장 효과적인 AIDS 치료법은 새로운 바이러스를 합성하는데 필요한 바이러스 효소를 비활성화하는 분자인 단백질 가수분해효소 억해제를 포함하는 여러 가지 약물을 사용하는 치료법이다. 마지막으로, 효소 억제의 연구를 통해 생화학자는 효소의 기능적 성질 뿐만 아니라 물리적 및 화학적 구조를 조사할 수 있는 기술을 개발할 수 있게 되었다.
효소 억제는 가역적이거나 비가역적이다. 가역적인 억제는 효소가 온전한 상태에서 기질 수준을 증가시키거나 억제제 화합물을 제거 함으로써 화합물의 억제 효과가 상쇄될 때 일어난다. 가역적인 억제는 억제제와 기질이 동일한 부위에 결합한다면 경쟁적이 되고, 억제제가 활성부위 이외에 결합하면 비경쟁적이며, 기질이 효소에 결합한 후에 억제제의 결합 부위가 생성되면 무경쟁적이 된다. 비가역적 억제는 일반적으로 효소를 화학적으로 변형하는 공유결합을 통하여 억제제의 결합이 효소에 영구히 손상을 가하게 되면 일어난다.
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Experience
Years of experience: 7. Registered at ProZ.com: Mar 2022. Became a member: Jun 2022.
- diverse background in medicine, biochemistry, food, nutrition, chemistry, and life science
- wide range of knowledge on medical terminology, mechanism of drug action, physiology of disease
-English to Korean translation of clinical trial, regulation-related documents, patents (biochemical/pharmaceutical/health science/chemical related), commercial brochure, medical/instrument protocol, business related documents.
- published many English written academic papers
- worked as reviewer at many internationally prestigious Journals
Member since Jun '22
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