Feb 7 14:58
3 mos ago
28 viewers *
English term

portal inflammatory changes

English to German Medical Medical (general)
Hallo,

dies ist aus einem medizinisch-pharmazeutischen Patent. Es geht um den Schutz von Organen.

Entzündliche Veränderungen von/der/des ...?

EN:
Hepatotoxic compounds inducing cholestasis, an arrest in the flow of bile, may take several forms.
Centribular cholestasis is accompanied by ***portal inflammatory changes***.
Bile duct changes have been reported with some drugs such as erythromycin, while pure canalicular cholestasis is characteristic of other drugs such as the anabolic steroids.

Gruß
Votes to reclassify question as PRO/non-PRO:

Non-PRO (1): Harald Moelzer (medical-translator)

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Proposed translations

1 day 46 mins
Selected

portale entzündliche Veränderungen

... mit einer centrilobulären Cholestase einhergehende portale entzündliche Veränderungen ...

(Im Englischen sollte es 'centrilobular' und nicht 'centribular' heißen)

Generell findet man in NASH-Lebern von Kindern und Jugendlichen weniger lobuläre, dafür vermehrt portale entzündliche Veränderungen und auch eher eine portale und weniger eine perisinusoidale, intraazinäre Fibrose. Diese histologische Besonderheit könnte die frühzeitige Progression des NAFLD-Score bei Kindern und Jugendlichen im Vergleich zu Erwachsenen erklären.
https://docplayer.org/47818299-S2k-leitlinie-nicht-alkoholis...


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3 KudoZ points awarded for this answer.
+1
1 hr

entzündliche Veränderungen der Pfortader oder Portalvene

Mit dem Kurzbegriff Pfortader ist meist jene der Leber gemeint. - https://www.netdoktor.at/anatomie/pfortader/

Das Metavir-Staging-System bewertet entzündliche Veränderungen (histologische Aktivität) und den Grad der Fibrose wie folgt - https://www.msdmanuals.com/de/profi/erkrankungen-der-leber,-...
Peer comment(s):

agree Expertlang
1 hr
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+1
6 hrs

portale Entzündung

Peer comment(s):

agree Anne Schulz : Ja, "portal" wie (Peri-)Portalfeld, Portalläppchen etc.
14 hrs
Thanks, Anne.
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Reference comments

9 mins
Reference:

clarification

https://www.sciencedirect.com/science/article/pii/S108932610...
by JH Lewis · 1999 · Cited by 74 — Jaundice occurred in a few individuals, and histologic changes of prominent cholestasis, portal inflammation, and injury to interlobular bile ducts similar to ...

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Note added at 13 minutos (2024-02-07 15:12:18 GMT)
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https://pubmed.ncbi.nlm.nih.gov/33575886/

The liver frequently reveals steatosis, liver cell necrosis, portal inflammation, and proliferation of Kupffer cells. Important preexisting diseases in autopsy studies are arterial hypertension with hypertensive and ischemic cardiomyopathy and diabetes mellitus but large population-based studies reveal increased risk of mortality only for diabetes mellitus not for arterial hypertension.

Die Nieren zeigen eine akute Tubulusschädigung als Ausdruck eines akuten Nierenversagens, Lymphknoten und Milz einen Schwund der Lymphozyten, die Nebennierenrinde eine Hyperplasie. In der Leber finden sich häufig eine Steatose, Leberzellnekrosen, ein portales Entzündungsinfiltrat und eine Proliferation der Kupffer-Zellen. Häufige Grunderkrankungen sind in den Autopsiekollektiven arterieller Hypertonus mit hypertensiver und ischämischer Kardiomyopathie und Diabetes mellitus.

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Note added at 15 minutos (2024-02-07 15:14:15 GMT)
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https://jlupub.ub.uni-giessen.de/bitstream/handle/jlupub/147...
portal betonte Schädigung und Inflammation unterstreichen eine durch die KMT ausge- ... Dabei entwickeln Abcb4-/- eine portale Inflammation, eine gesteigerte ...

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Note added at 16 minutos (2024-02-07 15:15:24 GMT)
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https://www.proz.com/kudoz/german-to-english/medical-general...

Entzündliche Veränderung




:inflammatory change

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Note added at 17 minutos (2024-02-07 15:16:19 GMT)
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Cholestasis with hepatitis, the second histologic pattern of cholestasis, is characterized by inflammatory changes in the portal tracts with evidence of hepatocellular injury or necrosis and is commonly associated with reactions to drugs

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Note added at 18 minutos (2024-02-07 15:17:17 GMT)
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evere shigellosis can cause a cholestatic hepatitis with portal and periportal polymorphonuclear inflammatory infiltrates,
Note from asker:
Thanks very much.
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