Membrane fusion, they explained, is a multi-step process that begins with the virus recognising that it's found the right type of cell to infect. To do this, the virus receives feedback from the chemical environment, including cues like the receptor that the host cell presents, the study noted. The virus then attaches to the host cell receptor by way of the spike protein on its surface, it said. (India Times)

Other host pathways determined to be highly important in SARS and MERS-CoV replication include vesicle trafficking within the endoplasmic reticulum of host cells. It has been determined that the replicase-transcriptase machinery of the coronavirus assembles at the host endoplasmic reticulum (ER) and viral structural proteins assemble within the host ER, making it an essential cellular component and potential drug target to block both viral genome replication and capsid assembly in the formation of new virus particles during infection. (Drug Target Review)

And although the mechanism by which ivermectin works against the virus is not known, Wagstaff suggested it is likely that, based on its action in other viruses, the drug acts to stop the virus dampening down the host cells’ ability to clear it. (GenEng News)