Glossary entry (derived from question below)
French term or phrase:
rationnel pharmacocinétique-pharmacodynamique
English translation:
pharmacokinetic/pharmacodynamic rationale
Added to glossary by
Drmanu49
Sep 8, 2012 17:13
11 yrs ago
4 viewers *
French term
rationnel pharmacocinétique-pharmacodynamique
French to English
Medical
Medical: Pharmaceuticals
Compte tendu d'un rationnel pharmacocinétique-pharmacodynamique face à la situation épidémiologique actuelle, des augmentations de doses par rapport aux posologies actuellement mentionnées dans les AMM concernées doivent être requises.
In view of the pharmacokinetic-pharmacodynamic rationale in the current epidemiological context, increases in doses versus the current MA dosages are required.
Any ideas about the "rationnel" ? What does it refer to and how do we say it in English?
Context: Evaluation of a fixed combination of antibiotics.
Thanks in advance.
In view of the pharmacokinetic-pharmacodynamic rationale in the current epidemiological context, increases in doses versus the current MA dosages are required.
Any ideas about the "rationnel" ? What does it refer to and how do we say it in English?
Context: Evaluation of a fixed combination of antibiotics.
Thanks in advance.
Proposed translations
(English)
Change log
Sep 10, 2012 09:33: Drmanu49 changed "Edited KOG entry" from "<a href="/profile/1633780">CMarc's</a> old entry - "rationnel pharmacocinétique-pharmacodynamique "" to ""pharmacokinetic/pharmacodynamic rationale""
Proposed translations
+3
18 mins
Selected
pharmacokinetic/pharmacodynamic rationale
jac.oxfordjournals.org/content/58/5/987.full.pdf - Traduire cette page
de JF Roos - 2006 - Cité 34 fois - Autres articles
Pharmacokinetic-pharmacodynamic rationale for cefepime dosing regimens in intensive care units. Juliana F. Roos1*, Jurgen Bulitta2, Jeffrey Lipman3 and Carl ...
Gatifloxacin and the elderly - Journal of Antimicrobial Chemotherapy
jac.oxfordjournals.org/content/52/3/435.full.pdf - Traduire cette page
de PG Ambrose - 2003 - Cité 53 fois - Autres articles
Journal of Antimicrobial Chemotherapy (2003) 52, 435–440. DOI: 10.1093/jac/dkg370. Advance Access publication 13 August 2003. 435 ...
Single-dose azithromycin for acute otitis media: A pharmacokinetic ...
www.currenttherapeuticres.com/article/.../abstract - Traduire cette page
de CD Rothermel - 2003 - Cité 22 fois - Autres articles
Single-dose azithromycin for acute otitis media: A pharmacokinetic/pharmacodynamic rationale. Constance D. Rothermel, PhD ...
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Note added at 19 minutes (2012-09-08 17:32:37 GMT)
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dictionary.reference.com/browse/rationale - Traduire cette page
the fundamental reason or reasons serving to account for something. 2. a statement of reasons. 3. a reasoned exposition of principles. Relevant Questions ...
de JF Roos - 2006 - Cité 34 fois - Autres articles
Pharmacokinetic-pharmacodynamic rationale for cefepime dosing regimens in intensive care units. Juliana F. Roos1*, Jurgen Bulitta2, Jeffrey Lipman3 and Carl ...
Gatifloxacin and the elderly - Journal of Antimicrobial Chemotherapy
jac.oxfordjournals.org/content/52/3/435.full.pdf - Traduire cette page
de PG Ambrose - 2003 - Cité 53 fois - Autres articles
Journal of Antimicrobial Chemotherapy (2003) 52, 435–440. DOI: 10.1093/jac/dkg370. Advance Access publication 13 August 2003. 435 ...
Single-dose azithromycin for acute otitis media: A pharmacokinetic ...
www.currenttherapeuticres.com/article/.../abstract - Traduire cette page
de CD Rothermel - 2003 - Cité 22 fois - Autres articles
Single-dose azithromycin for acute otitis media: A pharmacokinetic/pharmacodynamic rationale. Constance D. Rothermel, PhD ...
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Note added at 19 minutes (2012-09-08 17:32:37 GMT)
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dictionary.reference.com/browse/rationale - Traduire cette page
the fundamental reason or reasons serving to account for something. 2. a statement of reasons. 3. a reasoned exposition of principles. Relevant Questions ...
4 KudoZ points awarded for this answer.
4 mins
pharmacokinetic-pharmacodynamic thinking
Point of view
26 mins
Pharmacokinetic and pharmacodynamic reasoning
Quantitative Pharmacology: An Introduction to ... - Amazon.co.uk
www.amazon.co.uk › ... › Pharmaceutical Technology
Tennessee and University of Manchester. He has published extensively in the field of pharmacokinetic-pharmacodynamic modeling and reasoning, and has run ...
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Note added at 30 mins (2012-09-08 17:43:10 GMT)
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rationnel :: Lexipedia - Where words have meaning
www.lexipedia.com/french/rationnel
rationnel. adj. capable of being expressed as a quotient of integers; "rational numbers". rationnel. adj. consistent with or based on or using reason; "rational ...
French Translation of rational | Collins English French Dictionary
www.collinsdictionary.com/dictionary/english-french/rationa...
[decision, explanation, argument] rationnel(le); [solution] rationnel(le); [thought, thinking, mind, reasoning] rationnel(le). (psychology, psychiatry(= of sound mind) ...
www.amazon.co.uk › ... › Pharmaceutical Technology
Tennessee and University of Manchester. He has published extensively in the field of pharmacokinetic-pharmacodynamic modeling and reasoning, and has run ...
--------------------------------------------------
Note added at 30 mins (2012-09-08 17:43:10 GMT)
--------------------------------------------------
rationnel :: Lexipedia - Where words have meaning
www.lexipedia.com/french/rationnel
rationnel. adj. capable of being expressed as a quotient of integers; "rational numbers". rationnel. adj. consistent with or based on or using reason; "rational ...
French Translation of rational | Collins English French Dictionary
www.collinsdictionary.com/dictionary/english-french/rationa...
[decision, explanation, argument] rationnel(le); [solution] rationnel(le); [thought, thinking, mind, reasoning] rationnel(le). (psychology, psychiatry(= of sound mind) ...
+3
54 mins
pharmacokinetic-pharmacodynamic considerations
In view of the pharmacokinetic-pharmacodynamic considerations demanded by the current epidemiological situation
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Note added at 1 hr (2012-09-08 18:53:33 GMT)
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or strategies - even better
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Note added at 1 hr (2012-09-08 18:57:25 GMT)
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increases in doses versus the current MA dosages are required
I don't think so - there is no "versus"
des augmentations de doses par rapport aux posologies actuellement mentionnées dans les AMM concernées doivent être requises
increases in the dosages that have currently received marketing authorisation must be requested/demanded
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Note added at 1 hr (2012-09-08 18:53:33 GMT)
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or strategies - even better
--------------------------------------------------
Note added at 1 hr (2012-09-08 18:57:25 GMT)
--------------------------------------------------
increases in doses versus the current MA dosages are required
I don't think so - there is no "versus"
des augmentations de doses par rapport aux posologies actuellement mentionnées dans les AMM concernées doivent être requises
increases in the dosages that have currently received marketing authorisation must be requested/demanded
Peer comment(s):
| agree |
Nikki Scott-Despaigne
: Practical solution. The difficulty here is how to render "rationnel".
1 hr
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thanks Nikki - the challenge of texts like this is to understand what the author really wants to say and transform it into palatable English - IOW best to avoid literal translations
|
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| agree |
Helen Genevier
21 hrs
|
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thanks Helen :-)
|
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| agree |
Joanne Archambault
: I'd go with strategies here
1 day 19 hrs
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yes, that's what I prefer - thanks Joanne :-)
|
1 hr
pharmacokinetic-pharmacodynamic justification
Pharmacokinetic perspectives on megadoses of ascorbic acid.www.ajcn.org/content/66/5/1165You +1'd this publicly. Undo
by J Blanchard - 1997 - Cited by 53 - Related articles
As a consequence of this ceiling effect, there is no pharmacokinetic justification for the use of megadoses of ascorbic acid. « Previous | Next Article » Table of ...
[PDF]
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Note added at 1 hr (2012-09-08 19:07:27 GMT)
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[PDF]
Guideline on Strategies to Identify and Mitigate Risks for First-In ...www.ema.europa.eu/pdfs/human/swp/2836707enfin.pdfSimilar
You +1'd this publicly. Undo
File Format: PDF/Adobe Acrobat - Quick View
by ENDOF CONSULTATION - 2007 - Related articles
pharmacokinetic and pharmacodynamic parameters and the trial objectives such as justifying progression to the next cohort. While larger cohorts are likely to ...
[PDF]
Introduction to Pharmacokinetics and Pharmacodynamicswww.ashp.org/DocLibrary/Bookstore/P2418-Chapter1.aspxYou +1'd this publicly. Undo
File Format: PDF/Adobe Acrobat - Quick View
Lesson 1: Introduction to Pharmacokinetics and Pharmacodynamics. 3 regulation results in ...... drug concentrations would be a good justification for therapeutic ...
Dr Jürgen B Bulittawww.pharm.monash.edu.au › Faculty › StaffCached
You +1'd this publicly. Undo
Nov 16, 2011 – Application of Pharmacokinetic-Pharmacodynamic Modeling and Justification of a Novel Fusidic Acid Dosing Regimen: Raising Lazarus from ...
by J Blanchard - 1997 - Cited by 53 - Related articles
As a consequence of this ceiling effect, there is no pharmacokinetic justification for the use of megadoses of ascorbic acid. « Previous | Next Article » Table of ...
[PDF]
--------------------------------------------------
Note added at 1 hr (2012-09-08 19:07:27 GMT)
--------------------------------------------------
[PDF]
Guideline on Strategies to Identify and Mitigate Risks for First-In ...www.ema.europa.eu/pdfs/human/swp/2836707enfin.pdfSimilar
You +1'd this publicly. Undo
File Format: PDF/Adobe Acrobat - Quick View
by ENDOF CONSULTATION - 2007 - Related articles
pharmacokinetic and pharmacodynamic parameters and the trial objectives such as justifying progression to the next cohort. While larger cohorts are likely to ...
[PDF]
Introduction to Pharmacokinetics and Pharmacodynamicswww.ashp.org/DocLibrary/Bookstore/P2418-Chapter1.aspxYou +1'd this publicly. Undo
File Format: PDF/Adobe Acrobat - Quick View
Lesson 1: Introduction to Pharmacokinetics and Pharmacodynamics. 3 regulation results in ...... drug concentrations would be a good justification for therapeutic ...
Dr Jürgen B Bulittawww.pharm.monash.edu.au › Faculty › StaffCached
You +1'd this publicly. Undo
Nov 16, 2011 – Application of Pharmacokinetic-Pharmacodynamic Modeling and Justification of a Novel Fusidic Acid Dosing Regimen: Raising Lazarus from ...
Reference comments
2 hrs
Reference:
rationale
rationale
ra·tion·ale
noun
1.
the fundamental reason or reasons serving to account for something.
2.
a statement of reasons.
3.
a reasoned exposition of principles.
Origin:
1650–60; < Latin: neuter of ratiōnālis rational
Synonyms
1. logic, basis, grounds.
[http://dictionary.reference.com/browse/rationale]
ra·tion·ale
noun
1.
the fundamental reason or reasons serving to account for something.
2.
a statement of reasons.
3.
a reasoned exposition of principles.
Origin:
1650–60; < Latin: neuter of ratiōnālis rational
Synonyms
1. logic, basis, grounds.
[http://dictionary.reference.com/browse/rationale]
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